Pu Lab Publications


2010
  • Ikeda, S., and Pu, W. T. (2010). Expression and Function of MicroRNAs in Heart Disease. Curr Drug Targets. PDF
  • Kong, S.W., Hu, Y.W., Ho, J.W.K., Ikeda, S., Polster, S, John, R., Hall, J.L., Bisping, E., Pieske, B., do Remedios, C. G., and Pu, W. T. (2010) Heart Failure Associated Changes in RNA Splicing of Sarcomere Genes, Circulation: Cardiovascular Genetics. PDF
2009
  • Pu, W. T. (2009) Identification of a cardiac disease modifier gene using forward genetics in the mouse. PLoS Genet 5, e1000643. PDF
  • Zhou, B., Ma, Q., Kong, S. W., Hu, Y., Campbell, P. H., McGowan, F. X., Ackerman, K. G., Wu, B., Zhou, B., Tevosian, S. G. and Pu, W. T. (2009) Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest 119, 1462-1476. PDF
  • Zhou, B., von Gise, A., Ma, Q., Hu, Y. W., and Pu, W. T. (2010). Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol 338, 251-261. PDF
  • Ikeda, S., He, A., Kong, S. W., Lu, J., Bejar, R., Bodyak, N., Lee, K. H., Ma, Q., Kang, P. M., Golub, T. R. and Pu, W. T. (2009) MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol 29, 2193-2204 PDF
  • Wu, B., Zhou, B., Wang, Y., Cheng, H. L., Hang, C. T., Pu, W. T., Chang, C. P. and Zhou, B. (2009) Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse. Genesis 48, 63-72 PDF
2008
  • Zhou, B., Ma, Q., Rajagopal, S., Wu, S. M., Domian, I., Rivera-Feliciano, J., Jiang, D., von Gise, A., Ikeda, S., Chien, K. R. and Pu, W. T. (2008) Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 454, 109-113 PDF
  • Ma*, Q., Zhou*, B. and Pu, W. T. (2008) Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol 323, 98-104. *equal contributions PDF
  • Zhou, B. and Pu, W. T. (2008) More than a cover: epicardium as a novel source of cardiac progenitor cells. Regen Med 3, 633-635 PDF
  • Zhou, B., von Gise, A., Ma, Q., Rivera-Feliciano, J. and Pu, W. T. (2008) Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium. Biochem Biophys Res Commun 375, 450-453 PDF
  • Rojas, A., Kong, S. W., Agarwal, P., Gilliss, B., Pu, W. T. and Black, B. L. (2008) GATA4 is a direct transcriptional activator of Cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium. Mol Cell Biol 28, 5420-5431
  • Mellgren, A. M., Smith, C. L., Olsen, G. S., Eskiocak, B., Zhou, B., Kazi, M. N., Ruiz, F. R., Pu, W. T. and Tallquist, M. D. (2008) Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res 103, 1393-1401
2007
  • Ikeda*, S., Kong*, S. W., Lu, J., Bisping, E., Zhang, H., Allen, P. D., Golub, T. R., Pieske, B. and Pu, W. T. (2007) Altered microRNA expression in human heart disease. Physiol Genomics 31, 367-373. *equal contributions PDF
  • Rajagopal, S. K., Ma, Q., Obler, D., Shen, J., Manichaikul, A., Tomita-Mitchell, A., Boardman, K., Briggs, C., Garg, V., Srivastava, D., Goldmuntz, E., Broman, K. W., Woodrow Benson, D., Smoot, L. B. and Pu, W. T. (2007) Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol 43, 677-685 PDF
  • Zeisberg, E. M., Tarnavski, O., Zeisberg, M., Dorfman, A. L., McMullen, J. R., Gustafsson, E., Chandraker, A., Yuan, X., Pu, W. T., Roberts, A. B., Neilson, E. G., Sayegh, M. H., Izumo, S. and Kalluri, R. (2007) Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 13, 952-961 PDF
  • Jay, P. Y., Bielinska, M., Erlich, J. M., Mannisto, S., Pu, W. T., Heikinheimo, M. and Wilson, D. B. (2007) Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol 301, 602-614 PDF
  • Bodyak, N., Rigor, D. L., Chen, Y. S., Han, Y., Bisping, E., Pu, W. T. and Kang, P. M. (2007) Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes. Am J Physiol Heart Circ Physiol 293, H829-35
2006
  • Bisping, E., Ikeda, S., Kong, S. W., Tarnavski, O., Bodyak, N., McMullen, J. R., Rajagopal, S., Son, J. K., Ma, Q., Springer, Z., Kang, P. M., Izumo, S. and Pu, W. T. (2006) Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. Proc Natl Acad Sci U S A 103, 14471-14476 PDF
  • Rivera-Feliciano, J., Lee, K. H., Kong, S. W., Rajagopal, S., Ma, Q., Springer, Z., Izumo, S., Tabin, C. J. and Pu, W. T. (2006) Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 133, 3607-3618 PDF
  • Kong, S. W., Pu, W. T. and Park, P. J. (2006) A multivariate approach for integrating genome-wide expression data and biological knowledge. Bioinformatics 22, 2373-2380 PDF
  • Bosse, T., Piaseckyj, C. M., Burghard, E., Fialkovich, J. J., Rajagopal, S., Pu, W. T. and Krasinski, S. D. (2006) Gata4 Is Essential for the Maintenance of Jejunal-Ileal Identities in the Adult Mouse Small Intestine. Mol Cell Biol 26, 9060-9070
  • Han, Y., Chen, Y. S., Liu, Z., Bodyak, N., Rigor, D., Bisping, E., Pu, W. T. and Kang, P. M. (2006) Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Circ Res 99, 415-423
  • Buerger, A., Rozhitskaya, O., Sherwood, M. C., Dorfman, A. L., Bisping, E., Abel, E. D., Pu, W. T., Izumo, S. and Jay, P. Y. (2006) Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail 12, 392-398
2005
  • Zeisberg, E. M., Ma, Q., Juraszek, A. L., Moses, K., Schwartz, R. J., Izumo, S. and Pu, W. T. (2005) Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest 115, 1522-1531 PDF
2004
  • Pu, W. T., Ishiwata, T., Juraszek, A. L., Ma, Q. and Izumo, S. (2004) GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol 275, 235-244
  • Izumo, S. and Pu, W. T. (2004) in Heart Failure: A Companion to Braunwald's Heart Disease (Mann, D. L., ed.) pp. 10-40, Saunders, Philadelphia PDF
2003
  • Ishiwata, T., Nakazawa, M., Pu, W. T., Tevosian, S. G. and Izumo, S. (2003) Developmental Changes in Ventricular Diastolic Function Correlate With Changes in Ventricular Myoarchitecture in Normal Mouse Embryos. Circ Res 93, 857-865 PDF
2002
  • Wickman, K., Pu, W. T. and Clapham, D. E. (2002) Structural characterization of the mouse Girk genes. Gene 284, 241-250
2001
  • Kovoor, P., Wickman, K., Maguire, C. T., Pu, W. T., Gehrmann, J., Berul, C. I. and Clapham, D. E. (2001) Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. J Am Coll Cardiol 37, 2136-2143
  • Pu, W. T. and Izumo, S. (2001) Transcription factors and heart failure: does the stressed heart need a hand? J Mol Cell Cardiol 33, 1765-1767
2000
  • Pu, W. T., Wickman, K. and Clapham, D. E. (2000) ICln is essential for cellular and early embryonic viability. J Biol Chem 275, 12363-12366
pre-2000
  • Pu, W. T., Krapivinsky, G. B., Krapivinsky, L. and Clapham, D. E. (1999) pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Mol Cell Biol 19, 4113-4120
  • Krapivinsky, G., Pu, W. T., Wickman, K., Krapivinsky, L. and Clapham, D. E. (1998) pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J. Biol. Chem. 273, 10811-10814
  • Pu, W. T., Chung, T., Hoffer, F. A., Jonas, R. A. and Geva, T. (1996) Diagnosis and management of agenesis of the right lung and left pulmonary artery sling. Am J Cardiol 78, 723-727
  • Pu, W. T. and Struhl, K. (1993) Dimerization of leucine zippers analyzed by random selection. Nucleic Acids Res 21, 4348-4355
  • Pu, W. T. and Struhl, K. (1992) Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex. Nucleic Acids Res 20, 771-775
  • Tzamarias, D., Pu, W. T. and Struhl, K. (1992) Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity. Proc Natl Acad Sci U S A 89, 2007-2011
  • Pu, W. T. and Struhl, K. (1991) The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding. Proc Natl Acad Sci U S A 88, 6901-6905
  • Pu, W. T. and Struhl, K. (1991) Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding. Mol Cell Biol 11, 4918-4926
  • Pu, W. T., Kahn, R., Munn, M. M. and Rupp, W. D. (1989) UvrABC incision of N-methylmitomycin A-DNA monoadducts and cross-links. J Biol Chem 264, 20697-20704