Pu Lab Publications


2010
  • He, A. and Pu, W. T. (2010) Curr Protoc Mol Biol Chapter 21, Unit 21.20 PDF
  • Lage, K., Mollgard, K., Greenway, S., Wakimoto, H., Gorham, J. M., Workman, C. T., Bendsen, E., Hansen, N. T., Rigina, O., Roque, F. S., Wiese, C., Christoffels, V. M., Roberts, A. E., Smoot, L. B., Pu, W. T., Donahoe, P. K., Tommerup, N., Brunak, S., Seidman, C. E., Seidman, J. G. and Larsen, L. A. (2010) Dissecting spatio-temporal protein networks driving human heart development and related disorders. Mol Syst Biol 6, 381
  • Beuling, E., Kerkhof, I. M., Nicksa, G. A., Giuffrida, M. J., Haywood, J., aan de Kerk, D. J., Piaseckyj, C. M., Pu, W. T., Buchmiller, T. L., Dawson, P. A. and Krasinski, S. D. (2010) Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine. Gut 59, 888-895
  • Ikeda, S., and Pu, W. T. (2010). Expression and Function of MicroRNAs in Heart Disease. Curr Drug Targets. PDF
  • Kong, S.W., Hu, Y.W., Ho, J.W.K., Ikeda, S., Polster, S, John, R., Hall, J.L., Bisping, E., Pieske, B., do Remedios, C. G., and Pu, W. T. (2010) Heart Failure Associated Changes in RNA Splicing of Sarcomere Genes, Circulation: Cardiovascular Genetics. PDF
2009
  • Pu, W. T. (2009) Identification of a cardiac disease modifier gene using forward genetics in the mouse. PLoS Genet 5, e1000643. PDF
  • Zhou, B., Ma, Q., Kong, S. W., Hu, Y., Campbell, P. H., McGowan, F. X., Ackerman, K. G., Wu, B., Zhou, B., Tevosian, S. G. and Pu, W. T. (2009) Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest 119, 1462-1476. PDF
  • Zhou, B., von Gise, A., Ma, Q., Hu, Y. W., and Pu, W. T. (2010). Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. Dev Biol 338, 251-261. PDF
  • Ikeda, S., He, A., Kong, S. W., Lu, J., Bejar, R., Bodyak, N., Lee, K. H., Ma, Q., Kang, P. M., Golub, T. R. and Pu, W. T. (2009) MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol 29, 2193-2204 PDF
  • Wu, B., Zhou, B., Wang, Y., Cheng, H. L., Hang, C. T., Pu, W. T., Chang, C. P. and Zhou, B. (2009) Inducible cardiomyocyte-specific gene disruption directed by the rat Tnnt2 promoter in the mouse. Genesis 48, 63-72 PDF
2008
  • Zhou, B., Ma, Q., Rajagopal, S., Wu, S. M., Domian, I., Rivera-Feliciano, J., Jiang, D., von Gise, A., Ikeda, S., Chien, K. R. and Pu, W. T. (2008) Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 454, 109-113 PDF
  • Ma*, Q., Zhou*, B. and Pu, W. T. (2008) Reassessment of Isl1 and Nkx2-5 cardiac fate maps using a Gata4-based reporter of Cre activity. Dev Biol 323, 98-104. *equal contributions PDF
  • Zhou, B. and Pu, W. T. (2008) More than a cover: epicardium as a novel source of cardiac progenitor cells. Regen Med 3, 633-635 PDF
  • Zhou, B., von Gise, A., Ma, Q., Rivera-Feliciano, J. and Pu, W. T. (2008) Nkx2-5- and Isl1-expressing cardiac progenitors contribute to proepicardium. Biochem Biophys Res Commun 375, 450-453 PDF
  • Rojas, A., Kong, S. W., Agarwal, P., Gilliss, B., Pu, W. T. and Black, B. L. (2008) GATA4 is a direct transcriptional activator of Cyclin D2 and Cdk4 and is required for cardiomyocyte proliferation in anterior heart field-derived myocardium. Mol Cell Biol 28, 5420-5431
  • Mellgren, A. M., Smith, C. L., Olsen, G. S., Eskiocak, B., Zhou, B., Kazi, M. N., Ruiz, F. R., Pu, W. T. and Tallquist, M. D. (2008) Platelet-derived growth factor receptor beta signaling is required for efficient epicardial cell migration and development of two distinct coronary vascular smooth muscle cell populations. Circ Res 103, 1393-1401
2007
  • Ikeda*, S., Kong*, S. W., Lu, J., Bisping, E., Zhang, H., Allen, P. D., Golub, T. R., Pieske, B. and Pu, W. T. (2007) Altered microRNA expression in human heart disease. Physiol Genomics 31, 367-373. *equal contributions PDF
  • Rajagopal, S. K., Ma, Q., Obler, D., Shen, J., Manichaikul, A., Tomita-Mitchell, A., Boardman, K., Briggs, C., Garg, V., Srivastava, D., Goldmuntz, E., Broman, K. W., Woodrow Benson, D., Smoot, L. B. and Pu, W. T. (2007) Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol 43, 677-685 PDF
  • Zeisberg, E. M., Tarnavski, O., Zeisberg, M., Dorfman, A. L., McMullen, J. R., Gustafsson, E., Chandraker, A., Yuan, X., Pu, W. T., Roberts, A. B., Neilson, E. G., Sayegh, M. H., Izumo, S. and Kalluri, R. (2007) Endothelial-to-mesenchymal transition contributes to cardiac fibrosis. Nat Med 13, 952-961 PDF
  • Jay, P. Y., Bielinska, M., Erlich, J. M., Mannisto, S., Pu, W. T., Heikinheimo, M. and Wilson, D. B. (2007) Impaired mesenchymal cell function in Gata4 mutant mice leads to diaphragmatic hernias and primary lung defects. Dev Biol 301, 602-614 PDF
  • Bodyak, N., Rigor, D. L., Chen, Y. S., Han, Y., Bisping, E., Pu, W. T. and Kang, P. M. (2007) Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes. Am J Physiol Heart Circ Physiol 293, H829-35
2006
  • Bisping, E., Ikeda, S., Kong, S. W., Tarnavski, O., Bodyak, N., McMullen, J. R., Rajagopal, S., Son, J. K., Ma, Q., Springer, Z., Kang, P. M., Izumo, S. and Pu, W. T. (2006) Gata4 is required for maintenance of postnatal cardiac function and protection from pressure overload-induced heart failure. Proc Natl Acad Sci U S A 103, 14471-14476 PDF
  • Rivera-Feliciano, J., Lee, K. H., Kong, S. W., Rajagopal, S., Ma, Q., Springer, Z., Izumo, S., Tabin, C. J. and Pu, W. T. (2006) Development of heart valves requires Gata4 expression in endothelial-derived cells. Development 133, 3607-3618 PDF
  • Kong, S. W., Pu, W. T. and Park, P. J. (2006) A multivariate approach for integrating genome-wide expression data and biological knowledge. Bioinformatics 22, 2373-2380 PDF
  • Bosse, T., Piaseckyj, C. M., Burghard, E., Fialkovich, J. J., Rajagopal, S., Pu, W. T. and Krasinski, S. D. (2006) Gata4 Is Essential for the Maintenance of Jejunal-Ileal Identities in the Adult Mouse Small Intestine. Mol Cell Biol 26, 9060-9070
  • Han, Y., Chen, Y. S., Liu, Z., Bodyak, N., Rigor, D., Bisping, E., Pu, W. T. and Kang, P. M. (2006) Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition. Circ Res 99, 415-423
  • Buerger, A., Rozhitskaya, O., Sherwood, M. C., Dorfman, A. L., Bisping, E., Abel, E. D., Pu, W. T., Izumo, S. and Jay, P. Y. (2006) Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail 12, 392-398
2005
  • Zeisberg, E. M., Ma, Q., Juraszek, A. L., Moses, K., Schwartz, R. J., Izumo, S. and Pu, W. T. (2005) Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest 115, 1522-1531 PDF
2004
  • Pu, W. T., Ishiwata, T., Juraszek, A. L., Ma, Q. and Izumo, S. (2004) GATA4 is a dosage-sensitive regulator of cardiac morphogenesis. Dev Biol 275, 235-244
  • Izumo, S. and Pu, W. T. (2004) in Heart Failure: A Companion to Braunwald's Heart Disease (Mann, D. L., ed.) pp. 10-40, Saunders, Philadelphia PDF
2003
  • Ishiwata, T., Nakazawa, M., Pu, W. T., Tevosian, S. G. and Izumo, S. (2003) Developmental Changes in Ventricular Diastolic Function Correlate With Changes in Ventricular Myoarchitecture in Normal Mouse Embryos. Circ Res 93, 857-865 PDF
2002
  • Wickman, K., Pu, W. T. and Clapham, D. E. (2002) Structural characterization of the mouse Girk genes. Gene 284, 241-250
2001
  • Kovoor, P., Wickman, K., Maguire, C. T., Pu, W. T., Gehrmann, J., Berul, C. I. and Clapham, D. E. (2001) Evaluation of the role of I(KACh) in atrial fibrillation using a mouse knockout model. J Am Coll Cardiol 37, 2136-2143
  • Pu, W. T. and Izumo, S. (2001) Transcription factors and heart failure: does the stressed heart need a hand? J Mol Cell Cardiol 33, 1765-1767
2000
  • Pu, W. T., Wickman, K. and Clapham, D. E. (2000) ICln is essential for cellular and early embryonic viability. J Biol Chem 275, 12363-12366
pre-2000
  • Pu, W. T., Krapivinsky, G. B., Krapivinsky, L. and Clapham, D. E. (1999) pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Mol Cell Biol 19, 4113-4120
  • Krapivinsky, G., Pu, W. T., Wickman, K., Krapivinsky, L. and Clapham, D. E. (1998) pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J. Biol. Chem. 273, 10811-10814
  • Pu, W. T., Chung, T., Hoffer, F. A., Jonas, R. A. and Geva, T. (1996) Diagnosis and management of agenesis of the right lung and left pulmonary artery sling. Am J Cardiol 78, 723-727
  • Pu, W. T. and Struhl, K. (1993) Dimerization of leucine zippers analyzed by random selection. Nucleic Acids Res 21, 4348-4355
  • Pu, W. T. and Struhl, K. (1992) Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex. Nucleic Acids Res 20, 771-775
  • Tzamarias, D., Pu, W. T. and Struhl, K. (1992) Mutations in the bZIP domain of yeast GCN4 that alter DNA-binding specificity. Proc Natl Acad Sci U S A 89, 2007-2011
  • Pu, W. T. and Struhl, K. (1991) The leucine zipper symmetrically positions the adjacent basic regions for specific DNA binding. Proc Natl Acad Sci U S A 88, 6901-6905
  • Pu, W. T. and Struhl, K. (1991) Highly conserved residues in the bZIP domain of yeast GCN4 are not essential for DNA binding. Mol Cell Biol 11, 4918-4926
  • Pu, W. T., Kahn, R., Munn, M. M. and Rupp, W. D. (1989) UvrABC incision of N-methylmitomycin A-DNA monoadducts and cross-links. J Biol Chem 264, 20697-20704