Pu Lab Publications 2025


2025 Original Manuscripts


  • Lu, F.*†, Wu, Z.*, Chi, S.*, Wang, Y., Ponek, A., Ma, Q., Chen, C., Shi, B., Pavlaki, N., Liou, C., Tharani, Y., Prondzynski, M., Talab, S. S., Xie, W., Chen, Y. S., Guo, Z., Lipsitz, S. R., Zhang, D., van Petegem, F., Bezzerides, V. J. & Pu, W. T†. Direct therapeutic modulation of RYR2 activity by CMYA5. Circulation 152, 1179–1182 (2025). *contributed equally. †co-corresponding. PDF
  • Sweat, M. E.*, Shi, W.*, Sweat, Y. Y., Li, J., Li, J., Keating, E. M., Ponek, A., Ma, Q., Park, C., Trembley, M. A., Wang, Y., Hou, C., Bezzerides, V. J., Conlon, F. L.† & Pu, W. T.† TBX5 and CHD4 coordinately activate atrial cardiomyocyte genes to maintain cardiac rhythm homeostasis. Circulation (2025). doi:10.1161/CIRCULATIONAHA.125.073833 *contributed equally. †co-corresponding. PDF
  • Chen, D., Fan, X., Sun, N., Wang, K., Gong, L., Melero-Martin, J. M. & Pu, W. T. Pioneer factor ETV2 safeguards endothelial cell specification by recruiting the repressor REST to restrict alternative lineage commitment. Nat. Cardiovasc. Res. (2025). PDF. Research Briefing.
  • Yazawa, E., Keating, E. M., Wang, S., Sweat, M. E., Ma, Q., Xu, Y., Schlame, M. & Pu, W. T. A murine model of Barth syndrome with cardiac and skeletal muscle selective inactivation of tafazzin. Dis. Model. Mech. (2025). doi:10.1242/dmm.052077. Open access.
  • Bortolin, R. H. & Pu, W. T. Response by Bortolin and Pu to letter regarding article, “antisense oligonucleotide therapy for calmodulinopathy.” Circulation 151, e970–e971 (2025).

2025 Reviews/Editorials/Book Chapters

  • Bezzerides, V. J. & Pu, W. T. Translational research in pediatric cardiology. in Nadas’ Pediatric Cardiology (ed. Edward P. Walsh, John E. Mayer, Sarah A. Teele, & David W. Brown) 790–802 (Elsevier, 2025).

2025 Collaborative Work

  • Gong, L., Zhang, Y., Zhu, Y., Lee, U., Luo, A. C., Li, X., Wang, X., Chen, D., Pu, W. T., Lin, R.-Z., Ma, M., Cui, M., Chen, K., Wang, K. & Melero-Martin, J. M. Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages. Cell Stem Cell 32, 1200-1217.e6 (2025).
  • Chen, Z., Yang, L., Zhang, Y., Li, J., Yang, Y., Li, Y., Fan, L., Chen, W., Miao, L., Liu, J., Chen, G., Wang, Z., Li, Y., Gao, F., Zhou, J., Zheng, L., Zhang, Y., Zhao, D., Pu, W. T., Yang, K., Dong, E. & Guo, Y. The drug-elicitable alternative splicing module for tunable vector expression in the heart. Nat. Cardiovasc. Res. 4, 938–955 (2025).
  • Bortolin, R. H., de Souza Leite, F., Luchessi, A. D., Esposito, J., Barbosa, I. N., Freitas, R. C. C. de, Sonawane, A. R., Singh, S. A., Aikawa, E., Telles-Silva, K. A., Hirata, T. D. C., Rosa Neta, A. P., Goulart, E., Caires-Júnior, L. C., Mata Martins, T. M. da, Semedo, P., Moreira, D. de P., Naslavsky, M., Faludi, A. A., Gonçalves, R. M., Araujo, D. B., Malaquias, V. B., Ferreira, G. M., DeOcesano-Pereira, C., Chudzinski-Tavassi, A. M., Pu, W. T., Zatz, M., Hirata, R. D. C. & Hirata, M. H. Translational insights into statin-induced myotoxicity: Differential impact of lipophilic and hydrophilic statins on iPSC-derived skeletal muscle cells from patients with familial hypercholesterolemia. Toxicology 515, 154159 (2025).
  • Arulsamy, K., Xia, B., Yu, Y., Chen, H., Pu, W. T., Zhang, L. & Chen, K. SCIG: Machine learning uncovers cell identity genes in single cells by genetic sequence codes. Nucleic Acids Res. 53, (2025). PMC12117433
  • Yoshinaga, D., Craven, I., Feng, R., Prondzynski, M., Shani, K., Tharani, Y., Mayourian, J., Joseph, M., Walker, D., Bortolin, R. H., Carreon, C. K., Boss, B., Upton, S., Parker, K. K., Pu, W. T. & Bezzerides, V. J. Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy. Nat. Commun. 16, 3604 (2025).